PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
Anti-Infective, Disinfectant, Preservative
EXTRA NOTES
FEMA No. 2858
EPA Pesticide Chemical Code 001503
An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic
essence and preservative in pharmaceutics and perfumery
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT
SOLUBILITY IN WATER
SOLVENT SOLUBILITY
REFRACTIVE INDEX
102 C
EXTERNAL LINKS & GENERAL DESCRIPTION
Drug Information Portal (U.S. National Library of Medicine) - Phenylethyl alcohol
PubChem Compound Summary - Phenylethyl alcohol
KEGG (Kyoto Encyclopedia of Genes and Genomes) - Phenylethyl alcohol
http://www.ebi.ac.uk/chebi/ - Phenylethyl alcohol
http://www.ncbi.nlm.nih.gov/ - Phenylethyl alcohol
http://www.thegoodscentscompany.com/
http://www.efsa.europa.eu/
Flavouring
Group Evaluation 53 (FGE.53): Consideration of phenethyl alcohol,
aldehyde, acid and related acetals and esters evaluated by JECFA
(59th meeting) structurally related to phenethyl alcohol, aldehyde,
esters and related phenylacetic acid esters evaluated by EFSA in
FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006)
http://www.sciencedirect.com/
The
antibacterial activity of phenethylalcohol (PEA) towards Gram-negative
(Escherichia coli and Pseudomonas aeruginosa) and Gram-positive
bacteria (Staphylococcus aureus and Enterococcus faecium) was investigated.
This activity was expressed as IC (inhibitory concentration) and
BC (bactericidal concentration). PEA was bactericidal in the concentration
and range of 90 to 180 mM, these concentrations being 4- to 5-fold
higher than the corresponding IC. The mechanism of action of PEA
upon the cell membrane of bacteria was also studied. Morphological
examination with a transmission electron microscope showed that
Gram-negative cell envelopes were permeabilized; for Gram-positive
bacteria, the plasmic membrane in S. aureus was solubilized, whereas
lesser changes were observed in E. faecium. At lethal concentrations,
PEA also induced a rapid and total leakage of K+ ions from the four
strains studied. Despite the correlation between alterations in
the structural integrity of the cytoplasmic membrane in Gram-negative
cells and the loss of cell viability, it cannot be inferred that
membrane damage is the only cause of the lethal effect.
Local:
Phenylethyl is a structural skeleton found in sympathomimetic amines that have
important physiological functions within the body as neurotransmitters in the
central nervous system and hormones in the blood circulation. Phenyl ethyl alcohol might be an useful intermediate to prepare nervous system drugs.
Phenyl ethyl alcohol
is used as an biocide (antimicrobial, antiseptic, or disinfectant) and
as an aromatic
essence (particularly
rose and jasmine, lily) and as a preservative in pharmaceuticals and perfumery.
APPEARANCE
ASSAY
99.0% min
REFRACTIVE INDEX
1.531 - 1.534
SPECIFIC GRAVITY
1.017 - 1.020
HAZARD OVERVIEW
Harmful if absorbed through the skin. May be harmful if swallowed. May cause central nervous system depression. Causes eye, skin, and respiratory tract irritation. Target Organs: Central nervous system, eyes, skin, mucous membranes.
GHS
PICTOGRAMS
HAZARD STATEMENTS
H302 Harmful if swallowed
H311 Toxic in contact
with skin
H315 Causes skin irritation
H319 Causes
serious eye irritation
PRECAUTIONARY STATEMENTS
P280 Wear protective gloves/protective clothing/eye protection/face
protection
P302 + P352 IF ON SKIN: Wash with plenty of
soap and water
P301+ P312: IF SWALLOWED: Call a POISON
CENTER or doctor/physician if you feel unwell
P305 + P351 + P338
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing
Xn
Harmful
RISK PHRASES
21/22 Harmful in contact with skin and if swallowed.
36/38
Irritating to eyes and skin.
SAFETY PHRASES
26 In case of contact with eyes, rinse immediately with
plenty of water and seek medical advice.
36/37/39 Wear
suitable protective clothing, gloves and eye/face protection.
PRICE INFORMATION